Considering potential molecular targeted therapy, we performed comprehensive genomic profiling (CGP) (FoundationOne®, Cambridge, MA, USA) of the tumor sample, which revealed variants in MSH2 (p.I581Lfs*9), MSH3 (p.K383Rfs*32), NF1 (p.Y1607Lfs*15), PALB2 (p.M296*), CRF3R (p.G72R), RB1 (p.A74Efs*4), TET2 (p.N482*) and TP53 (p.R248Q) (Supplementary Table 1). The gene discussed is MSH2; the disease is neoplasm.