Nuclear factor-κB (NF-κB) denotes a family of inducible transcription factors that regulate multiple important physiological and pathological cellular processes.1 Several studies have indicated that NF-κB is excessively or inappropriately activated in a variety of pathological cellular processes, especially inflammation and cancer.2–5 NF‐κB activation occurs via two major signaling pathways: the canonical and the non‐canonical NF‐κB signaling pathways. Here, NFKB1 is linked to cancer.