HMOX1 and cardiomyopathy: Fang et al. reported that suppressing HO-1 expression helped mitigate ferroptosis in cardiomyopathy both in vivo and in vitro.14 Tang et al. found that inhibiting HO-1 activity was a robust and efficient method of protecting the retinal pigment epithelium from ferroptosis.43 These studies indicated that HO-1 is a double-edged sword, playing various roles in different tissues and different disease models.