Eckhardt et al. first reported that DM led to substantial accumulation of injured osteocytes with a proinflammatory signature.8 Yang et al. demonstrated that high glucose significantly inhibited the biomechanical responses of osteocytes by downregulating the expression of the gap junction protein connexin 43 (Cx43).9 Despite these findings, the specific mechanism of osteocyte injury in the diabetic microenvironment is still unclear. This evidence concerns the gene GJA1 and diabetes mellitus.