While DSS severely inhibited growth of wild-type LI1 and LI2 organoids, even at the lowest concentration tested (0.5 μg/mL) (Figure 3, A and B), Ade1 and Ade2 adenoma organoid lines were completely DSS resistant, even at the highest dose of 6 μg DSS/mL (Figure 3, A and B). The gene discussed is PAICS; the disease is adenoma.