When diagnostic genetic testing is undertaken in an individual with wtGIST, PPGL, renal cancer, neuroblastoma or pituitary tumour and a PGV identified, including SDHA c.91C>T p.(Arg31*), provided other causes have been excluded or there is appropriate immunohistochemical evidence (see table 1 footnotes), the PGV can be considered to be associated with the clinical phenotype and the diagnostic laboratory report should reflect this. The gene discussed is SDHA; the disease is renal carcinoma.