To investigate the effects of TNFR2 on the tumorigenesis of pancreatic cancer in vivo, KPC cells, with or without anti-TNFR2 antibody pretreatment, were subcutaneously inoculated into immunocompetent C57BL/6 and immunodeficient nude mice, separately. This evidence concerns the gene TNFRSF1B and pancreatic neoplasm.