To further validate the effects of TNFR2 on the in vivo growth and progression of pancreatic cancer, immunocompetent C57BL/6 and immunodeficient nude mice were injected orthotopically with control or KPC-shTNFR2 (Tnfr2 knockdown by short hairpin RNA (shRNA)) cells. The gene discussed is TNFRSF1B; the disease is familial pancreatic carcinoma.