For example, TREM2 c.140G>A (p.Arg47His) is associated with increased risk for AD in European descent populations [129, 130] but not in African [128] or Asian [131, 132], while TREM2 c.469C>T (p.His157Tyr) shows association with AD in Asian [127, 133] but not in European [134] or African [128] cohorts. The gene discussed is TREM2; the disease is Alzheimer disease.