Preliminarily, we have found that living PD patients with mild to moderate disease severity based on Uniform Parkinson Disease Rating Scale scores have (1) increased α-syn deposition in dermal sympathetic nerve fibers, (2) myocardial NE deficiency as indicated by 18F-DA-derived radioactivity, (3) normal immunoreactive TH in sympathetic noradrenergically innervated dermal constituents, and (4) normal NE content in skin tissue. Here, TH is linked to Parkinson disease.