HDAC2 and glioblastoma: Because HDAC2 knockdown was highly influential in inducing GBM cell death to provide the direct evidence that HDAC2 knockdown induced GLUT3-mediated cell death via miR-3189 upregulation, we investigated the luciferase activity of pmirGLO-GLUT3wt in HDAC2 knockdown GBM cells by doxycycline treatment (Fig. 4F).