GLUT3 siRNA or miR-3189 mimics synergistically decreased the glucose uptake (Fig. 5E and F) and lactate production (Fig. 5G and H) in shHDAC2-expressing GBM cells than individually transfected GBM cells, but the change of glucose uptake and lactate production did not observe in GLUT1 or GLUT2 knockdown GBM cells (Additional file 1: Fig. S4D and E). This evidence concerns the gene SLC2A1 and glioblastoma.