In many studies, the reduced glucose uptake and lactate production in glucose metabolism has been known to inhibit tumor cell viability.15 Therefore, to consider whether cell death and proliferation in GBM cells might correlate with glucose metabolism, we examine that the repression of GLUT3 by HDAC2 knockdown induces GBM cell death via inhibition of glucose metabolism. Here, SLC2A3 is linked to glioblastoma.