We also investigated cellular proliferation by expressing GLUT3 siRNA, miR-3189 mimics, and HDAC2 siRNA in GBM cells, confirming that both GLUT3 knockdown and miR-3189 overexpression decreased GBM proliferation, similar to HDAC2 knockdown (Additional file 1: Fig. S4C). This evidence concerns the gene HDAC2 and glioblastoma.