A total of 18 m6A regulators, namely, METTL3, WTAP, RBM15, RBM15B, CBLL1, ZCCHC4, YTHDC1, YTHDF1/2/3, LRPPRC, HNRNPA2B1, HNRNPC, IGF2BP1/2/3, ELAVL1, and FTO, were found to be associated with overall survival (OS) in HCC patients from TCGA and GSE76427 cohorts using Kaplan–Meier curves and log-rank tests (Additional file 1: Fig. S2). This evidence concerns the gene YTHDF1 and hepatocellular carcinoma.