We have recently described that transcriptome and proteome of pituitary adenomas segregate into three distinct clusters, according to the transcription factor that drives their terminal differentiation: NR5A1-derived gonadotrophinomas which constitute the majority of CNFPA; TBX19-derived clinically evident ACTH-secreting tumors causing Cushing disease; and POU1F1-derived somatotrophinomas, prolactinomas and thyrotrophinomas [15, 16]. This evidence concerns the gene POMC and pituitary gland adenoma.