Importantly, DC-SIGN is involved in multiple aspects of the immunological response [38]; Yvette van Kooyk’s laboratory proposed that DC-SIGN can actively contribute to the maintenance of an immunosuppressive tissue environment [39]; as previously described, CD169+ macrophages, which are known as CD169+ suppressive macrophages [18], play a role in various diseases; but the role of DC-SIGN+ CD169+ macrophages in the pathogenesis of endometriosis has not been studied. Here, SIGLEC1 is linked to endometriosis.