TNF and eosinophilia-myalgia syndrome: FOXP3+ Treg cells secrete cytokines, such as CCL22, CCL17, transforming growth factor-1 (TGF-1), interleukin (IL)-1, tumor necrosis factor (TNF), IL-8 and vascular endothelial growth factor (VEGF), while cooperating with other immune cells to promote the progression of EMS [23].