Since PlGF has recently been added to some screening programs to improve the accuracy of first trimester aneuploidy screening, maternal characteristics (questionnaire) combined with biochemical markers (blood test) could be used as a first-tier test to identify women for secondary MAP (physical test) and UTPI (ultrasound scan), allowing for the expansion of current aneuploidy screening programs to include PE screening. This evidence concerns the gene PGF and aneuploidy.