Moreover, a recent study showed that diabetic conditions negatively regulates antioxidant properties in endothelial cells and this effect was associated with acetylation of p53 and increased expression of p300 (Di Tomo et al. 2021) These findings are in accordance with our results showing that elevated lysine acetylation is associated with dysfunctional VSMCs in diabetes. This evidence concerns the gene TP53 and diabetes mellitus.