RAP2B and familial pancreatic carcinoma: To demonstrate the function of RAP2B in pancreatic cancer, it was stably silenced in SW1990 and MIAPaCa-2 cells, and the results show that the expression of phosphorylated ERK in RAP2B-silenced MIAPaCa-2 and SW1990 cells was reduced compared with the corresponding control cells (Fig. 3C).