Importantly, CCNL1 knockdown imitated, while overexpression reversed, the effects of miR-5195-3p overexpression on PCa cell proliferation and cell cycle G1/S transition.<h4>Conclusions</h4>Our data suggest that miR-5195-3p functions as a tumor suppressor by targeting CCNL1 in PCa. This evidence concerns the gene CCNL1 and neoplasm.