Bin1, for example, was identified as an Alzheimer’s disease locus through GWAS studies (Seshadri et al., 2010), and localizes to the axon initial segment and nodes of Ranvier acting downstream of c-myc, an injury-response transcription factor in RGCs (Belin et al., 2015). Here, BIN1 is linked to early-onset autosomal dominant Alzheimer disease.