Previous studies have shown that late-stage STING vesicles are sorted to lysosomes for trafficking-mediated STING degradation [73] and that the autophagic cargo receptor SQSTM1 mediates the autophagic degradation of STING in human acute monocytic leukemia cells under HSV-1 stimulation [57]. The gene discussed is SQSTM1; the disease is acute monocytic leukemia.