For studying BRD4ʹs impacts on mouse colitis, repressive BRD4 was in mice (Figure 4a), and it came out the reduction of BRD4 reduced DAI scores (Figure 4b), alleviated the weight loss of mice (Figure 4c), and the length of the colon was longer vs. DSS mice (Figure 4d), reduced gross damage score (Figure 4e), colonic inflammatory cell infiltration, and apoptotic cells were presented (Figures 4f-g). Here, BRD4 is linked to colitis.