In previously untreated EGFR-mutant advanced NSCLC, osimertinib was compared to gefitinib or erlotinib in the randomized phase III Flaura trial: 22% of patients that received osimertinib presented BM compared with 24% treated with erlotinib or gefitinib. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.