Although the model does not demonstrate the classical pathological hallmark of PD, which is the accumulation of α-synuclein and Lewy bodies, it expresses the cardinal processes in PD, including mitochondrial dysfunction, apoptosis, ROS induced oxidative stress, neuro-inflammation, lipid peroxidation and disruption in endogenous antioxidant enzymes (Dias et al. 2013). The gene discussed is SNCA; the disease is Parkinson disease.