Preclinical studies showed that NAM enhanced expansion (60-80 fold) of functional donor NK cells in feeder-free cultures stimulated with IL-2 and IL-15 for 2 weeks and the expanded NK cells with NAM displayed the increased in vitro cytotoxicity against Burkitt lymphoma (BL) cells, in vivo homing, and survival in immunodeficient mice [79]. The gene discussed is IL15; the disease is Burkitt lymphoma.