Next, the decrease of active efflux CL at the BTB compared with the control brain BBB was estimated in 7 out of 9 cases (Table VI), which is consistent with recent publication reporting significant reduction of ABCB1 and ABCG2 protein abundances in isolated MV of GBM in human patients compared with non-cancerous cerebral cortex (38). This evidence concerns the gene ABCG2 and glioblastoma.