PRRT2 and Chronic colitis: For example, in animal models of intestinal inflammatory disease (chronic colitis), PKC- θ KO mice showed decreased T cell proliferation and cytokines production (Chand et al., 2012; Curnock et al., 2014; Nicolle et al., 2021), suggesting that PKC-θ inhibitors could be useful as a therapeutic approach for inflammatory disorders (Chand et al., 2012; Curnock et al., 2014).