Thus, the PKC-θ:SHP-1 axis may play an important role in NK immune surveillance and tumor clearance, a topic that has recently gained much attention in the immunotherapy field, especially in the context of adoptive cell transfer and genetically engineered NK cells (Dotta et al., 2007; Morandi et al., 2008; Ahern and Brennan, 2011; Jochems et al., 2016; Siegler et al., 2017). Here, PTPN6 is linked to neoplasm.