As expected, PKC-θ-silenced NK cells exhibited decreased antitumor activity toward activating target cells (721-Cw7), while mice engrafted with YTS-2DL1 SHP-/- gene-silenced to PKC-θ exhibited a stronger antitumor response with lower tumor growth rates, suggesting that loss of SHP-1 activity restored the NK antitumor responses (p<0.0001, Figure 8D and E, Figure 8—figure supplement 1). This evidence concerns the gene PTPN6 and neoplasm.