PTPN6 and neoplasm: As shown in Figures 7E and 8D and E, YTS-2DL1 cells gene-silenced for PKC-θ show reduced degranulation, resulting in increased tumor growth rates, whereas YTS-2DL1 SHP-1 KO cells treated with PKC-θ siRNA (DKO) show increased degranulation and reduced tumor growth rate relative to YTS-2DL1 cells gene-silenced for PKC-θ, suggesting that SHP-1 knockout rescues the antitumor response.