To better understand the similarity and heterogeneity of KIR+CD8+ T cells under different circumstances, we performed scRNA-seq on 4512 KIR+CD8+ T cells sorted from healthy subjects and patients with MS, SLE, or CeD using the Smart-seq2 protocol (26) and analyzed their TCR α and β sequences (27). Here, KIR3DL1 is linked to systemic lupus erythematosus.