To further investigate whether KIR+CD8+ T cells are the phenotypic equivalent of mouse Ly49+ T cells in humans, we performed RNA sequencing (RNA-seq) analysis on KIR+ versus KIR–CD8+ T cells from patients with MS to compare with mouse Ly49+CD8+ T cells in EAE, a mouse model of human MS. This evidence concerns the gene KIR3DL1 and myeloid sarcoma.