In our previous study, we demonstrated that CD146 inhibits the egression of macrophages from atheroma plaques during atherosclerosis.[19] In this study, we observed that interleukin 4 (IL‐4)‐induced M2‐like macrophages have lower levels of CD146 expression (Figure S4A,B, Supporting Information) and higher migration ability (Figure S4C,D, Supporting Information) than lipopolysaccharide (LPS)/ interferon gamma (IFN‐γ)‐induced M1‐like macrophages. The gene discussed is MCAM; the disease is atherosclerosis.