ANGPTL2 and obesity due to melanocortin 4 receptor deficiency: Our recent study also showed adipocytes CD146 as a receptor for angiopoietin‐like protein 2 (ANGPTL2) to promote adipogenesis and adipose inflammation.[62] In macrophages, CD146 interacted with Gp130 but not with ANGPTL2, suggesting that CD146 plays complex and multiple roles in diet‐induced obesity.