The IL‐6 induced STAT3 activation was negatively regulated by other regulators, such as the well‐known negative regulator, Suppressor Of Cytokine Signaling 3 (SOCS3),[31] and Protein Inhibitor Of Activated STAT 3 (PIAS3).[32] To further elucidate how CD146 negatively regulates the STAT3 activation, we tested the above mentioned regulators in M‐WT and M‐KO BMDMs under hyperlipidemia conditions or IL‐6 stimulation. Here, PIAS3 is linked to hyperlipidemia.