Interestingly, the ratio of CD11c+CD206− to CD11c−CD206+ cells among F4/80+ macrophages between ND and HFD mice did not differ significantly (Figure 1A,B); however, the percent of CD11c+CD206+ cells was notably increased upon diet‐induced obesity (Figure 1C). Here, ITGAX is linked to obesity due to melanocortin 4 receptor deficiency.