CD146 has also been reported to function in association with CD36, a multifunctional class B scavenger receptor.[19] CD36 is highly expressed on macrophages and adipocytes, implicating its role in the development of insulin resistance and diabetes.[57, 58] CD36 functions as a principal receptor for the uptake of long‐chain fatty acids and oxidized lipids, thereby leading to lipid loading and foam cell formation, and its internalization triggers inflammatory signaling cascades. Here, MCAM is linked to Insulin resistance.