MCAM and obesity due to melanocortin 4 receptor deficiency: In contrast, HFD‐fed M‐KO mice displayed greater energy expenditure than their WT control littermates (Figure 2G,H); however, no difference was detected in their RER and physical activities (Figure 2I and Figure S2F, Supporting Information), suggesting that CD146+ macrophages are associated with obesity‐induced metabolic changes.