CD11c+CD206+ macrophages were described as a novel macrophage subset to facilitate adipose tissue inflammation and insulin resistance in obese human subjects and mice models.[9, 46] In mice, CD11c+CD206+ ATMs were markedly increased with the prolonged HFD supplementation.[47] CD11c+CD206+ ATMs in humans were reported to have features of classically activated macrophages (M1), yet also have features of alternatively activated macrophages (M2),[9] suggesting that CD11c+CD206+ ATMs have a dual role in adipose tissue. The gene discussed is MRC1; the disease is Insulin resistance.