Interestingly, frailty, malnutrition, and cachexia often co‐exist in older individuals; in a recent study examining more than 110 000 older individuals across the UK, frailty was detected in >90% of patients characterized by malnutrition and in 100% of patients characterized by cachexia,21 while recent studies suggest an inverse relationship between CFS and albumin or BMI.22 This evidence concerns the gene ALB and Cachexia.