ACE and cardiovascular disorder: Longitudinal analyses have reported an increased incidence of CKD (hazard ratio 1.25) and somewhat faster eGFR decline (0.22–0.45 ml/min per 1.73 m2/yr) in individuals with SCT14,15; male sex, diabetes, hypertension, cardiovascular disease, and use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, aspirin, and statins were associated with faster eGFR decline, while higher Hb levels were associated with slower eGFR decline in those with SCT.15