In multivariable analysis, SCT (adjusted odds ratio 1.62 [95% CI 1.14–2.32]) and APOL1 high-risk genotypes (4.88 [3.57–6.67]) as well as age, prior AIDS, recent CD4 cell count, diabetes, and cardiovascular disease remained associated with eGFR <60 ml/min per 1.73 m2 (Table 2 and Supplementary Table S2). Here, CD4 is linked to diabetes mellitus.