Longitudinal analyses have reported an increased incidence of CKD (hazard ratio 1.25) and somewhat faster eGFR decline (0.22–0.45 ml/min per 1.73 m2/yr) in individuals with SCT14,15; male sex, diabetes, hypertension, cardiovascular disease, and use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, aspirin, and statins were associated with faster eGFR decline, while higher Hb levels were associated with slower eGFR decline in those with SCT.15 The gene discussed is GSTM1; the disease is diabetes mellitus.