NR1H4 and obesity due to melanocortin 4 receptor deficiency: To further verify the effect of the enterohepatic FXR-FGF15 axis on the CGA-induced inhibition of obesity, C57BL/6 mice were administered the FXR antagonist Z-Gug and FXR agonist GW4064 to inhibit or increase FXR expression, respectively [18].