In addition, our research verified the positive correlation between serum baseline levels of IgG, IgE, eosinophils, history of asthma, and symptom duration in IgG4-ROD patients, indicating that as the duration of symptoms increases, serum baseline levels of IgE and eosinophils accumulate in the body and are more likely to accompany asthma. Here, IGHE is linked to asthma.