Namely, the AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, and TNF signaling pathway are the three main DBD signaling pathways, and PDE3A and PTGS1 are the potential key genes, while quercetin and hederagenin are the two main active ingredients crucial for NSCLC treatment. This evidence concerns the gene PDE3A and non-small cell lung carcinoma.