PPARG and non-small cell lung carcinoma: PPARG expression may also act as a potential therapeutic agent for NSCLC, especially for lung squamous cell carcinoma (LSCC), since the activation of PPARG expression can inhibit LSCC development and progress by regulating the upstream regulator and downstream marker genes, which are involved in tumor cell proliferation and protein polyubiquitination/ubiquitination [50].