Our study results revealed that the highly expressed genes were associated with poor prognosis, PDE3A was associated with overall survival in all NSCLC patients (p = 0.0384), while the overall survival analysis of other nine core genes with high and low expression did not have any statistical significance (p < 0.05) which is shown in Figure 9. The gene discussed is PDE3A; the disease is non-small cell lung carcinoma.