Our study results revealed that the coaction targets were mainly enriched in several diseases: lipid-induced atherosclerosis, hepatitis B, shear stress-induced atherosclerosis, etc., and also participated in different signaling pathways, including the AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, and TNF signaling pathway. The gene discussed is IL17A; the disease is hepatitis B virus infection.