The primary aim of our study was to identify clinical and biochemical features that were associated with the need for insulin as a new treatment in people with known type 2 diabetes (T2DM) not on insulin treatment at the time of hospitalisation for SARS-CoV-2 infection and to describe changes in insulin requirements at the time of discharge from the hospital and 6 weeks later during the first wave of SARS-CoV-2 infection (April–March 2020) in the UK. The gene discussed is INS; the disease is type 2 diabetes mellitus.