High PD-1 and GITR expression levels have been also found in tumor-infiltrating lymphocytes among different cancer indications based on messenger RNA sequencing (mRNA-seq) analysis (University of California at San Francisco (UCSF) immunoprofiler initiative) and immunohistochemistry (IHC), as previously suggested (Extended Data Fig. 2a,b and Supplementary Table 1)24. This evidence concerns the gene TNFRSF18 and neoplasm.