IRF7 and acute myeloid leukemia: When AML cells were sorted based on c-kit expression and transplanted into secondary recipients, AML-WT-c-kit- cells gave rise to approximately 25% c-kit+ cells, while AML-WT-c-kit+ and AML-IRF7−/−-c-kit+ cells gave rise to similar levels of c-kit+ cells as the first transplantation (Fig. 2H, Supplementary Fig. S2B).