GSEA between AML-WT-c-kit+ and AML-IRF7−/−-c-kit+ cells demonstrated that the annotations, i.e., Cell cycle and embryonic stem cell core associated genes were enriched in AML-IRF7−/−-c-kit+ cells, whereas leukocyte differentiation associated genes were enriched in AML-WT-c-kit+ cells (Fig. 4A). The gene discussed is IRF7; the disease is acute myeloid leukemia.