Notably, VCAM1+ cells were only detected in the c-kit+ population of AML-WT cells (Supplementary Fig. S9D), while the positive rate and MFI of VCAM1 were higher in the c-kithigh population of AML-IRF7−/− cells than in either the c-kitlow or the c-kit- population (Supplementary Fig. S9E). Here, IRF7 is linked to acute myeloid leukemia.