Limiting dilution transplantation experiments showed that 1 × 103 AML cells caused 100% mortality in AML-IRF7−/− mice but approximately 90% mortality in AML-WT mice, while 1 × 102 AML cells caused approximately 90% mortality in AML-IRF7−/− mice but no mortality in AML-WT mice (Fig. 2E). This evidence concerns the gene IRF7 and acute myeloid leukemia.