Moreover, the presence of the hypoxia-inducible factor (HIF1α; ΔPSI = 0.16; AF) and prostaglandin-endoperoxide synthase 2 (PTGS2; ΔPSI = 0.11; AF), which are engaged in the response to LPS, indicates that LPS treatment increased the inclusion level of AFEs in both genes. The gene discussed is HIF1A; the disease is atrial fibrillation.