The greatest changes in the alternative splicing ratio were noted in PPP1R21 (ΔPSI = 0.75; AL) and GJB1 (ΔPSI = 0.59; AF), whereas the lowest inclusion levels were observed in SEC24B (ΔPSI = − 0.75; AF) and ERI3 (ΔPSI = − 0.65; AL). Here, PPP1R21 is linked to atrial fibrillation.