The ratios of inflammatory cells CD4/CD8, and CD138/CD3 in ICIs (0.63 and 0.044) were significantly lower than those in AIH (1.89 and 0.21) or DILI (1.08 and 0.39) patients (p < 0.05, respectively) (Fig. 3A). This evidence concerns the gene CD8A and autoimmune hepatitis.