ADRB2 and neoplasm: The β2-AR agonist properties of (R,R′)-MNF would initially appear to be counterintuitive for the treatment of PDAC as catecholamine activation of β2-ARs increases tumor growth in KPC mice and PDAC xenograft models22,23 and promotes MEK/ERK signaling in PANC-1, BxPC-3 and MIA PaCa-2 PDAC cells22.