Immunoblotting experiments confirmed the significant and sustained downregulation of key pro-oncogenic signaling proteins, such as YAP, HIF-1α, c-Myc, CYR61 and β-catenin, but not cyclin D1 nor LATS1/2 in PANC-1 tumor xenografts one week after the withdrawal of (R,S′)-MNF (Fig. 5H and I and data not shown). Here, LATS1 is linked to neoplasm.