HIF1A and neoplasm: Taken as a whole, the data obtained from the metabolomics and transcriptomics analysis of PANC-1 tumor tissues indicate that treatment with (R,S′)-MNF resulted in a metabolic deprogramming characterized by decreased glycolysis, alterations in fatty acid metabolism, and pyrimidine synthesis, and that these changes are consistent with reduced expression of HIF-1α and c-Myc.