The data suggest that GPR55 inhibition alone does not hinder tumor growth and that tumor inhibition observed with (R,S′)-MNF is the cooperative effect of GPR55 antagonistic properties and biased β2-AR agonism leading to selective PKA activation that is not observed with the non-biased agonism produced by (R,R′)-MNF. The gene discussed is ADRB2; the disease is neoplasm.