Here, (R,S′)-MNF exerted a potent repression of the Hippo-YAP/TAZ signaling in PANC-1 tumor xenografts with the downregulation of genes encoding key mediators (TAOK1, MST2, MOBK1B), transcriptional regulators (WWTR1, TEAD4), and downstream pro-survival genes CYR61, BIRC2, and MCL1 (Fig. 5E and Supporting Information Table S7). Here, TEAD4 is linked to neoplasm.