PFKFB4 and neoplasm: In the current study, gene expression profiling and immunoblotting analyses of PDAC-derived tumor xenografts indicate that administration of (R,S′)-MNF significantly reduced gene and protein expression of HIF-1α and c-Myc and attenuated gene expression of multiple components of the glycolytic pathway, including GLUT1 transporter (Slc2a1), PFKFB4, PGK2, and LDHA.