Twelve weeks of endurance exercise ameliorated obesity and atherosclerotic lesions through decreases in chemokines (VCAM-1 and MCP-1) and inflammatory cytokines (IL-1β and TNF-α) as well as the microbiota associated with inflammation (Desulfovibrio, Tyzzerella, and Lachnospiraceae_ge) and SCFA production (Desulfovibrio, Tyzzerella, and Lachnospiraceae_ge). The gene discussed is VCAM1; the disease is obesity disorder.