Twelve weeks of endurance exercise ameliorated obesity and atherosclerotic lesions through decreases in chemokines (VCAM-1 and MCP-1) and inflammatory cytokines (IL-1β and TNF-α) as well as the microbiota associated with inflammation (Desulfovibrio, Tyzzerella, and Lachnospiraceae_ge) and SCFA production (Desulfovibrio, Tyzzerella, and Lachnospiraceae_ge). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.