We were not able to reproduce data regarding the treatment of NHL cells with ERβ agonists, such as DPN and a highly selective Erβ agonist KB9520 [35]; instead, we demonstrated that treatment with the clinically available SERM tamoxifen and the selective estrogen β antagonist PHTPP resulted in DLBCL cell death. The gene discussed is ESR2; the disease is diffuse large B-cell lymphoma.