CACNA1C and osteoporosis: Moreover, Fei et al. found that Cav1.2 per se facilitates the osteogenesis of bone marrow-derived mesenchymal stem cells, and upregulation of Cav1.2 expression alleviated osteoporosis in premature aging mice.44 However, Cav1.2 exhibited consistent expression among the two sets of transgenic preosteoblasts and the wild-type controls in the present study.