Moreover, the low expression of GZMA and F2R was positively correlated with PD-1 and PD-L1 (Fig. S7), impaired tumor suppression by PD-1 mAb (Fig. 7, Fig. S8, Fig. 9), and also predicted aggressive clinicopathological characteristics and a poor prognosis (Fig. 8, Fig. S10, and Fig. S11). The gene discussed is CD274; the disease is neoplasm.