In an ovalbumin (OVA) model antigen system, OVA-specific CD8+ T cells exhibited increased cytotoxicity toward OVA-positive tumor cells on injection of macrophages that had been co-cultured with OVA-expressing target cells in the presence of anti-CD47 antibody.49 The study suggests that the SIRPα–CD47 blockade augments the ability of macrophages to stimulate antigen-specific CD8+ T cells responses. This evidence concerns the gene SIRPA and neoplasm.