One study classified TME into four different types based on the status of tumor infiltrating lymphocytes (TILs) and PD-L1 expression [51] and found that the PFS and ORR of ICIs clearly differed according to the different TME types (ORR and median PFS; Type I: 64%, 14.5 months, Type II: 12%, 2.1 months, Type III: 24%, 3.6 months, Type IV: 41%, 10.8 months) [51]. This evidence concerns the gene CD274 and neoplasm.