They also observed that patients' synovial fluid have more CD56bright NK cells secreting IFN-γ than their peripheral blood [156], while in patients with systemic lupus erythematosus (SLE), there is a change in the ratio of CD56bright: CD56dim and an increase in the CD56bright subsets [157, 158]. This evidence concerns the gene IFNG and systemic lupus erythematosus.