As a mediator for IL-4 and IL-13 acting on downstream inflammatory cells, IL-4R complex participate in multiple signaling pathways that related to AD immune dysregulation [42, 43].Yun et al. [44] reported treating 2,4-dinitrochlorobenzene (DNCB)-induced AD mice with echinochrome A (an anti-inflammatory and anti-oxidative drug), revealing that echinochrome A appeared to suppress the expression and secretion of the proinflammatory cytokine IL-4 and IL-13. This evidence concerns the gene IL4 and Alzheimer disease.