To assessed the immunoregulatory effects of secretory factors produced by ADSCs, Vasilev et al. [68] co-cultured ADSC-conditioned medium with peripheral blood mononuclear cells from rheumatoid arthritis patients, with the co-culture system demonstrating an increase in the Treg/Th17 ratio, as well as in the expression of TGF-β and a decrease in IL-17 production. This evidence concerns the gene TGFB1 and rheumatoid arthritis.