The inflammatory diseases associated with the gene expression changes were also identified, and the most significantly related conditions were “Inflammation of joint,” “Cell movement of phagocytes,” and “Rheumatoid arthritis.” This pathway overlap supports the expected inflammatory arthritic phenotype in TNF-Tg mice, and also the increase of inflammatory monocytes determined in Fig. 3 (Fig. 5D). Here, TNF is linked to rheumatoid arthritis.