HAVCR2 and hepatocellular carcinoma: Circ-UHRF1 (ubiquitin-like with PHD and ring finger domain 1), existed in plasma exosomes secreted by HCC patients, which leading to immunosuppression by inhibiting NKs (natural killer cells) activity via circUHRF1/miR-449c-5p/TIM-3(T cell immunoglobulin domain and mucin domain 3) axis [38].