And the latest research noted that Cripto-1 [also named teratocarcinoma-derived growth factor 1 (TDGF-1)], largely existed in exosomes isolated from the serum of perihilar cholangiocarcinoma (PHCCA) patients versus cholangitis patients and normal controls, performed a better diagnostic capacity than CEA and CA19-9 (AUC: 0.82; Sensitivity: 79.1%; Specificity: 87.5%). Here, CRIPTO is linked to cholangitis.