Furthermore, more and more literatures have proved that in the testes with hyperglycemia, the expression profiles of apoptosis related proteins Bax and the Bax/Bcl-2 ratio were upregulated, as well Bcl-2 was downregulated, which was accompanied with the increasing number of apoptotic spermatogenic cells [34, 35]. The gene discussed is BAX; the disease is Hyperglycemia.