A non-linear relationship between the BRI level and the incidence of T2DM was detected after adjusting the confounding variables (age, gender, SBP, DBP, smoking status, ethanol consumption, habit of exercise, ALT, AST, GGT, FBG, HbA1c, HDL-C, TC, TG) (Fig. 6). The gene discussed is GPT; the disease is type 2 diabetes mellitus.