LncRNAs, such as LUCAT1, KCNMB2-AS1, CASC15, MIAT, PTOV1-AS2, LINC00680, and RNF217-AS1 [45–50] were reported to be up-regulated in ESCC and other malignant tumors, validating our RNA-sequencing results. The gene discussed is RNF217; the disease is esophageal squamous cell carcinoma.