In this study, a large number of lncRNAs were identified to be expressed aberrantly through transcriptomic analysis of ESCC tumor samples and matched normal tissues, of which LUCAT1 [45], CASC15 [47], MIAT [48], ZNF503-AS1, [67] and STXBP5-AS1 [68] have been shown to either promote or inhibit tumorigenesis in ESCC as well as other malignant tumors. Here, STXBP5 is linked to esophageal squamous cell carcinoma.